博士 1995.09-1998.06 南京师范大学 动物学
硕士 1982.02-1984.12 山东大学 动物学
本科 1978.02-1981.01 山东师范大学 生物学
工作经历
1997.9-至今 山东大学 教授
1992.09-1997.07 山东大学 副教授
1987.09-1992.07 山东大学 讲师
1984.12-1987.07 山东大学 助教
科研方向
无脊椎动物先天免疫:近二十年来一直从事无脊椎动物先天免疫研究,研究工作包括病原的模式识别,信号转导途径和效应分子等。主持国家自然科学基金重点项目2项和面上项目多项、国家863和省部级项目多项、参加973项目3项。以通讯作者在PLoS Pathogens, The Journal of Immunology, Journal of Virology 和 Journal of Biological Chemistry等SCI刊物发表论文100余篇。
主持课题
1. 2018.12-2022.12 水产动物疫病发生的分子基础与免疫机制—病原诱导的先天免疫信号通路与调控网络,国家重点研发计划。2. 2017.01-2021.12 对虾体内的微生物菌群及其动态平衡调控。国家自然科学基金重点项目。
3. 2015.01—2018.12 清道夫受体在对虾先天免疫防御中的功能研究。国家自然科学基金面上项目。
4. 2012.01—2016.12 对虾抗病毒相关基因的功能与抗病毒机理分析。国家自然科学基金重点项目。
5. 2012.01-2016.12 对虾白斑综合征防治的免疫学途径和关键技术原理,973项目。
学术兼职
中国动物学会理事,山东动物学会理事长
Developmental & Comparative Immunology, Heliyon等杂志编委。
代表论文 (*通讯作者)
16. Niu GJ, Wang S, Xu JD, Yang MC, Sun JJ, He ZH, Zhao XF, Wang JX*. The polymeric immunoglobulin receptor-like protein from Marsupenaeus japonicus is a receptor for white spot syndrome virus infection. PLoS Pathog. 2019 Feb 6;15(2):e1007558.
15. Niu GJ, Xu JD, Yuan WJ, Sun JJ, Yang MC, He ZH, Zhao XF, Wang JX*. Protein inhibitor of activated STAT (PIAS) negatively regulates the JAK/STAT pathway by inhibiting STAT phosphorylation and translocation. Front Immunol. 2018 Oct 26; 9:2392.
14. Xu JD, Diao MQ, Niu GJ, Wang XW, Zhao XF, Wang JX*. A small GTPase, RhoA, inhibits bacterial infection through integrin mediated phagocytosis in invertebrates. Front Immunol. 2018 Aug 30;9:1928.
13. Sun JJ, Xu S, He ZH, Shi XZ, Zhao XF, Wang JX*. Activation of Toll Pathway Is Different between Kuruma Shrimp and Drosophila. Front Immunol. 2017 Sep 20; 8:1151.
12. Sun JJ, Lan JF, Zhao XF, Vasta GR, Wang JX*. Binding of a C-type lectin's coiled-coil domain to the Domeless receptor directly activates the JAK/STAT pathway in the shrimp immune response to bacterial infection. PLoS Pathog. 2017 Sep 20;13(9):e1006626.
11. Wang XW*, Gao J, Xu YH, Xu JD, Fan ZX, Zhao XF, Wang JX*. Novel pattern recognition receptor protects shrimp by preventing bacterial colonization and promoting phagocytosis. J. Immunol. 2017 Apr 15;198(8):3045-3057
10. Xu JD, Jiang HS, Wei TD, Zhang KY, Wang XW, Zhao XF, Wang JX*. Interaction of the small GTPase Cdc42 with arginine kinase restricts white spot syndrome virus in shrimp. J. Virol. 2017 March; 91(5):e01916-16. This article was chosen by editors as a significant interested article: http://jvi.asm.org/content/91/5/e00017-17.full
9. Yang MC, Shi XZ, Yang HT, Sun JJ, Xu L, Wang XW, Zhao XF, Wang JX*. Scavenger receptor C mediates phagocytosis of white spot syndrome virus and restricts virus proliferation in shrimp. PLoS Pathog. 2016 Dec 27; 12(12):e1006127.
8. Sun JJ, Lan JF, Shi XZ, Yang MC, Niu GJ, Ding D, Zhao XF, Yu XQ, Wang JX*.β-Arrestins Negatively Regulate the Toll Pathway in Shrimp by Preventing Dorsal Translocation and Inhibiting Dorsal Transcriptional Activity. J. Biol. Chem. 2016 Apr 1;291(14):7488-504.
7. Wang XW, Xu YH, Xu JD, Zhao XF, Wang JX*.Collaboration between a soluble C-type lectin and calreticulin facilitates white spot syndrome virus infection in shrimp. J. Immunol. 2014 Sep 1;193(5):2106-17.
6. Wang XW, Xu JD, Zhao XF, Vasta GR, Wang JX*. A shrimp C-type lectin inhibits proliferation of the hemolymph microbiota by maintaining the expression of antimicrobial peptides. J. Biol. Chem. 2014 Apr 25; 289(17):11779-90.
5. Wang XW, Zhao XF, Wang JX*. C-type lectin binds to β-integrin to promote hemocytic phagocytosis in an invertebrate. J. Biol. Chem. 2014 Jan 24; 289(4):2405- 2414.
4. Lan JF, Li XC, Sun JJ, Gong J, Wang XW, Shi XZ, Shi LJ, WengYD Zhao XF, Wang J-X* Prohibitin interacts with envelope proteins of white spot syndrome virus and prevents infection in red swamp crayfish Procambarus clarkii. J. Virol. 2013 Dec; 87(23):12756-65.
3. Chen AJ, Gao L, Wang XW, Zhao XF, Wang JX*. SUMO conjugating enzyme E2 UBC9 mediates viral immediate-early protein SUMOylation in crayfish to facilitate reproduction of white spot syndrome virus. J. Virol. 2013 Jan; 87(1):636-47.
2. Chen AJ, Wang S, Zhao X-F, Yu XQ, Wang JX*. E2 enzyme from Chinese White Shrimp inhibits replication of white spot syndrome virus and ubiquitinates its RING domain proteins. J. Virol. 2011 Aug; 85(16):8069-79.
1. Wang S, Liu N, Chen AJ, Zhao XF, Wang JX*. TRBP homologue interacts with eukaryotic initiation factor 6 (eIF6) in Fenneropenaeus chinensis. J. Immunol. 2009 May 1; 182(9):5250-5258.
专利
1. 王金星,赵小凡,克氏原鳌虾阿肽西啶抗菌肽基因及其所编码的抗菌肽与应用, 2010年 9月13日授权,专利号: ZL200810159647.3
2. 王金星,赵小凡 克氏原鳌虾i型溶菌酶及其编码的溶菌酶与应用,授权日2011年9月29日,专利号:ZL201010254793.1.
3. 王金星,赵小凡 中国明对虾泛素连接酶基因及其编码的泛素连接酶与应用 授权日2012年5月23日,专利号: ZL201010254801.2.
4. 王金星,兰江风,赵小凡 克氏原螯虾抑制素1基因及其编码的抑制素1蛋白与应用 授权日:2014年11月26日 专利号:ZL201310289986.4.
奖励
1. 对虾抗细菌与抗病毒的先天免疫防御机理,2011年1月, 教育部高等学校科学研究优秀成果奖—自然科学一等奖。